pentobarbital will decrease the level or effect of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with strong CYP3A4 inducers may result in lowered serum concentrations and lack of antimalarial efficacypentobarbital will lessen the extent or result of bortezomib by aff